Hitting the unsubscribe button in your inbox can be both safe and risky, depending on the situation. While reputable companies generally follow email marketing regulations and unsubscribing from their emails should do the trick, doing the same with unknown senders might lead to more spam. It is important to differentiate between trusted sources and random emails, marking the latter as spam instead of unsubscribing. Additionally, utilizing spam filters and third-party tools like Unroll.Me, Clean Email, and MailWasher can help in managing and eliminating unwanted emails.